1Password - for maintaining passwords on Mac. It also works on the iPhone.

Evernote - for just about EVERYTHING. Syncs from my Macbook and is accessible via Macbook and iPhone.

Entourage - email app for Mac (calendar, etc.)

And use a good titling system for files and folders for easy searching.

STRONG BOOK RECOMMENDATION: Upgrade Your Life: The Lifehacker Guide To Working Smarter, Faster, Better by Gina Trapani